Eat breakfast for a healthy heart

A new study appears to confirm that when you eat is just as important for health as what and how much you eat.
US researchers asked men to complete questionnaires about what they ate and when they ate it, then tracked their health for 16 years. Those who said they skipped breakfast were found to have a higher risk of heart attack or fatal coronary heart disease.
Lead author Leah Cahill, of the Harvard School of Public Health (HSPH), and colleagues, write about their findings in a July 23rd issue of the American Heart Association journal Circulation.
In a statement, Leah Cahill, who is a postdoctoral research fellow in the department of nutrition at HSPH, explains what may lie behind the findings:

"Skipping breakfast may lead to one or more risk factors, including obesity, high blood pressure, high cholesterol and diabetes, which may in turn lead to a heart attack over time."

For their study the researchers analyzed food frequency questionnaires completed by 26,902 male health professionals aged between 45 and 82 years and tracked their health for 16 years from 1992 to 2008. The men were free of heart disease and cancer at the start of the study.
Over the follow-up, 1,572 men experienced non-fatal heart attacks or died of coronary heart disease.
When they analyzed the data the researchers found men who said they did not have breakfast had a 27% higher risk of heart attack or death from coronary heart disease than men who said they ate breakfast.

Men who skipped breakfast had other risk factors

The men who said they skipped breakfast tended to be younger, single, smokers, who worked full time, did not do much exercise and drank more alcohol.
The researchers also found when they adjusted the results to take out the effect of body mass index, high blood pressure, high cholesterol and diabetes, the links between skipping breakfast and higher risk for heart attack or death from coronary heart disease became much weaker: they were no longer statistically significant.
They note this suggests "eating habits may affect risk of coronary heart disease through pathways associated with these traditional risk factors."
They also found no links between how many times a day the men said they ate and risk of coronary heart disease.

Eating late at night linked to heart disease

They did find a link, however, between eating late at night and coronary heart disease. Compared with men who said they did not eat late at night, among those who did, there was a 55% higher risk of coronary heart disease.
But the authors note that, judging by the few men in the study who ate late at night, this was unlikely to be a major public health concern.
Leah Cahill says the message from the study, which reinforces previous research, is: "Don't skip breakfast." Eating a healthy meal at the start of the day is linked to lower risk of heart attacks.

Breakfast tips

Incorporate many types of healthy foods into your breakfast, Leah Cahill advises - as this is "an easy way to ensure your meal provides adequate energy and a healthy balance of nutrients, such as protein, carbohydrates, vitamins and minerals."
If eating a bowl of cereal, try adding nuts and chopped fruit, or steel-cut oatmeal. This is a "great way to start the day," Leah Cahill adds.
Senior author Eric Rimm, associate professor of medicine at the Harvard Medical School, says the team has spent decades looking at the effects of quality and composition of diet on health, and now this new study suggests overall dietary habits should also be considered in lowering risk of heart disease.
At a conference in 2012, UK scientists presented a study that explained why people who skip breakfast tend to find high calorie food more appealing later in the day: their brain circuits may be primed toward seeking it when fasting.

Middle-Aged Men May Need More Protein To Maintain Muscle Mass

People tend to lose muscle mass as they age; researchers are investigating ways to delay or counteract age-related muscle loss. A study conducted by the Exercise Metabolism Research Group at McMaster University suggests that current guidelines for meat consumption are based on the protein needed to prevent deficiency without consideration for preservation of muscle mass, particularly for older individuals who are looking to maintain their muscle as they age. This research was published in the journal Applied Physiology, Nutrition, and Metabolism.

Thirty-five middle-aged men (~59 years old) participated in a study that found that eating a 6-ounce serving of 85% lean ground beef resulted in significant improvements in the rate of muscle protein synthesis following exercise. The investigators measured muscle protein synthesis (MPS), which is essential to the body's ongoing growth, repair and maintenance of skeletal muscle in men who did and did not lift weights. What researchers determined was that the quantity of beef needed for optimal MPS for this age group is double the current recommended serving size of meat.

"Canada's Food Guide now suggests that consuming about 3oz (0.80 g/kg/d) of meat per serving is adequate to provide protein at the recommended level," says Dr. Stuart Phillips, the study's senior author and a researcher with the Exercise Metabolism Research Group at McMaster University. "However, our work shows that the quantity of beef needed to maximize the renewal of new muscle proteins was at least 6oz in middle-aged men. Our findings have clear ramifications for the current recommendations regarding protein to prevent muscle loss in aging."

Purified Extracts From Green Tea And Red Wine Interrupt Alzheimer's Disease Pathway In Cells

Natural chemicals found in green tea and red wine may disrupt a key step of the Alzheimer's disease pathway, according to new research from the University of Leeds.

In early-stage laboratory experiments, the researchers identified the process which allows harmful clumps of protein to latch on to brain cells, causing them to die. They were able to interrupt this pathway using the purified extracts of EGCG from green tea and resveratrol from red wine.

The findings, published in the Journal of Biological Chemistry, offer potential new targets for developing drugs to treat Alzheimer's disease, which affects some 800,000 people in the UK alone, and for which there is currently no cure.

"This is an important step in increasing our understanding of the cause and progression of Alzheimer's disease," says lead researcher Professor Nigel Hooper of the University's Faculty of Biological Sciences. "It's a misconception that Alzheimer's is a natural part of ageing; it's a disease that we believe can ultimately be cured through finding new opportunities for drug targets like this."

Alzheimer's disease is characterised by a distinct build-up of amyloid protein in the brain, which clumps together to form toxic, sticky balls of varying shapes. These amyloid balls latch on to the surface of nerve cells in the brain by attaching to proteins on the cell surface called prions, causing the nerve cells to malfunction and eventually die.

"We wanted to investigate whether the precise shape of the amyloid balls is essential for them to attach to the prion receptors, like the way a baseball fits snugly into its glove," says co-author Dr Jo Rushworth. "And if so, we wanted to see if we could prevent the amyloid balls binding to prion by altering their shape, as this would stop the cells from dying."

The team formed amyloid balls in a test tube and added them to human and animal brain cells. Professor Hooper said: "When we added the extracts from red wine and green tea, which recent research has shown to re-shape amyloid proteins, the amyloid balls no longer harmed the nerve cells. We saw that this was because their shape was distorted, so they could no longer bind to prion and disrupt cell function.

"We also showed, for the first time, that when amyloid balls stick to prion, it triggers the production of even more amyloid, in a deadly vicious cycle," he added.

Professor Hooper says that the team's next steps are to understand exactly how the amyloid-prion interaction kills off neurons.

"I'm certain that this will increase our understanding of Alzheimer's disease even further, with the potential to reveal yet more drug targets," he said.

Dr Simon Ridley, Head of Research at Alzheimer's Research UK, the UK's leading dementia research charity, which part-funded the study, said: "Understanding the causes of Alzheimer's is vital if we are to find a way of stopping the disease in its tracks. While these early-stage results should not be a signal for people to stock up on green tea and red wine, they could provide an important new lead in the search for new and effective treatments. With half a million people affected by Alzheimer's in the UK, we urgently need treatments that can halt the disease - that means it's crucial to invest in research to take results like these from the lab bench to the clinic."

Coffee Drinking Tied To Urinary Incontinence In Men

Men who consume about two cups of coffee a day, or the equivalent amount of caffeine, are significantly more likely to have urinary incontinence or a "leaky bladder" than men who drink less or none at all, according to new research from the US.
Senior author Alayne D. Markland, a professor at the University of Alabama at Birmingham, and colleagues, report their findings in a paper published online 2 January in The Journal of Urology.

In their background information they note while several studies have already established a link between caffeine intake and leaky bladder in women, the evidence for such a link in men is limited.

For their study, the researchers used national survey results from NHANES 2005-06 and 2007-08. This gave them data on over 5,000 American men aged 20 and over, with complete data available on nearly 4,000 of them.

The survey had collected information about food and drink intake which allowed the researchers to work out the men's caffeine consumption, water intake, and the total moisture content of their diet.

The survey data also included Incontinence Severity Index scores, for which a value of 3 and above is rated moderate to urinary incontinence (UI). Moderate to severe UI is more than a few drops of urine leakage in a month.

After adjusting for other potential influencers, the researchers found the men who consumed the most caffeine were more likely to have a leaky bladder than those who consumed the least or none at all.

Their analysis shows men who consumed 234 or more mg per day of caffeine were 72% more likely to have moderate to severe UI than men who consumed the least or none at all.

Men with a daily caffeine intake of 392 mg per day were more than twice as likely to have leaky bladder problems.

In contrast, men's total water intake was not linked to their risk for moderate to severe UI.

The researchers conclude:

"Caffeine consumption equivalent to approximately 2 cups of coffee per day (250mg) is significantly associated with moderate-severe UI in US men."

They call for further studies to look into this link.

Although the researchers did not establish whether coffee drinking causes men's leaky bladder problem, Markland told the press "It's something to consider ..."
People who are having problems with urinary incontinence should modify their caffeine intake and I think that's part of clinical practice," she says, in a statement reported by Reuter's Health